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Treatment

In vitro fertilisation (IVF)

In vitro fertilisation (IVF) is a treatment where eggs are collected from the ovaries and combined with sperm in a laboratory. If fertilisation is successful, one or more resulting embryos can be transferred to the uterus. A full cycle usually takes about three to six weeks.

What IVF involves

IVF is a multi-step treatment carried out over several weeks. According to the NHS, a full cycle usually takes about three to six weeks and follows the same broad stages: suppressing your natural cycle, ovarian stimulation, egg collection, fertilisation in the laboratory, embryo transfer, and a waiting period before a pregnancy test. The exact plan is tailored to your situation by your clinic.

Who IVF may help

The HFEA (the UK regulator) lists common reasons for IVF, including blocked or damaged fallopian tubes, unexplained infertility, low sperm count or quality (often with ICSI), ovulation problems, and situations where less invasive treatments such as IUI are less likely to work — for example with increasing age. Whether IVF is the right step depends on your diagnosis and history, which a clinician can help you weigh up.

Availability on the NHS (UK)

Some IVF is funded by the NHS, but eligibility is decided locally by your Integrated Care Board, so criteria — including age limits and the number of funded cycles — vary by area. NICE guideline NG257 sets national recommendations, but local funding rules differ, so it is worth checking what applies where you live. Many people use private clinics, either fully or to top up funded care.

Understanding success rates

Success rates vary with age, the cause of infertility, and other factors such as weight and smoking. Published figures describe groups of patients over a defined period; they are not a prediction for any individual. When comparing clinics, use age-banded data and check whether a figure is quoted per cycle started or per embryo transfer. Our understanding success rates page explains how to read this data.

Risks to be aware of

Most people tolerate IVF well, but it carries real risks. The main ones are ovarian hyperstimulation syndrome (OHSS) and, if more than one embryo is transferred, multiple pregnancy. The HFEA notes that about a third of people get mild OHSS, while severe OHSS is uncommon. Other risks include ectopic pregnancy (around 1%) and the usual risks of a minor procedure at egg collection. Your clinic should explain how it minimises these risks in your plan.

Be cautious with paid “add-ons”

Some clinics offer optional extras (“add-ons”) on top of standard IVF. The HFEA rates these by the strength of the evidence, and warns that most have limited or uncertain evidence of improving your chance of a baby. For most people, standard cycles work without add-ons — see our costs page and ask your clinic why any add-on is recommended for you specifically.

Questions to ask your clinic

  • What is your recommended plan for my situation, and why?
  • How do you decide how many embryos to transfer?
  • How do you report success rates, and for which patient group?
  • Are you recommending any add-ons, and what is the evidence for them?
  • What are the total expected costs, including medication and storage?

Typical steps

  1. Suppressing your natural cycle — Medication is used for around two weeks to pause your natural menstrual cycle so the clinic can control the timing of the next stages. (About 2 weeks (protocols vary).)
  2. Ovarian stimulation — Daily hormone injections encourage the ovaries to mature several eggs at once, tracked with blood tests and ultrasound scans, followed by a trigger injection to ripen the eggs. (Usually around 10–14 days.)
  3. Egg collection — Eggs are collected through the vagina using a fine needle under ultrasound guidance, typically under sedation. It takes roughly 20 minutes. (A single procedure, timed after the trigger injection.)
  4. Fertilisation in the laboratory — Collected eggs are combined with sperm in the lab (or a single sperm is injected per egg with ICSI where indicated). Fertilised eggs that develop are monitored as embryos. (Embryos are usually cultured for 2–5 days.)
  5. Embryo transfer — Usually a single embryo is placed into the uterus through a thin catheter. Any suitable remaining embryos may be frozen for later use. (A short outpatient procedure.)
  6. Luteal support and pregnancy test — Progesterone is often used to support the womb lining, and a pregnancy test is done after around two weeks. (About 2 weeks after transfer.)

Potential benefits

  • Can help with many causes of infertility, including tubal, male-factor, ovulation-related, endometriosis-related, and unexplained infertility.
  • Allows suitable embryos to be frozen for future attempts without repeating ovarian stimulation.
  • Can be combined with techniques such as ICSI where there is a sperm-related reason.

Risks to be aware of

  • Ovarian hyperstimulation syndrome (OHSS); most cases are mild, but severe OHSS occurs in a small minority of cycles (reported as around 1–2%) and can occasionally be serious.
  • Multiple pregnancy if more than one embryo is transferred, which raises risks for parent and babies — elective single embryo transfer reduces this.
  • Ectopic pregnancy (reported at roughly 1%), where the embryo implants outside the uterus.
  • Discomfort, bruising, or reactions from injections and the egg-collection procedure; uncommonly bleeding, infection, or injury to nearby organs.
  • Emotional and financial strain, especially if several cycles are needed, and no guarantee of success in any cycle.
Medical review complete
Written by
Sam Rivera · Health writer
Medically reviewed by
Dr Lena Park · Reproductive endocrinologist (medical reviewer)
Last reviewed
Next review due

Sources

  1. IVFNHS · Published 15 April 2025 · Accessed 19 July 2026
  2. HFEA: treatments, add-ons, and choosing a clinicHuman Fertilisation and Embryology Authority (HFEA) · Published 1 January 2024 · Accessed 19 July 2026
  3. Risks of fertility treatmentHuman Fertilisation and Embryology Authority (HFEA) · Published 7 April 2016 · Accessed 19 July 2026
  4. Treatment add-ons with limited evidenceHuman Fertilisation and Embryology Authority (HFEA) · Published 16 October 2023 · Accessed 19 July 2026
  5. ESHRE guidelines on assisted reproductive technology and ovarian stimulationEuropean Society of Human Reproduction and Embryology (ESHRE) · Published 1 May 2019 · Accessed 30 June 2026
  6. ReproductiveFacts.org patient resourcesAmerican Society for Reproductive Medicine (ASRM) · Accessed 19 July 2026
  7. Fertility problems: assessment and treatment (NICE guideline NG257)National Institute for Health and Care Excellence (NICE) · Published 31 March 2026 · Accessed 19 July 2026

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